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POU domain, class 2, transcription factor 1; NF-A1; octamer-binding protein 1; Oct-1; octamer-binding transcription factor 1; OTF-1 (POU2F1, OCT1, OTF1)
Function:
- transcription factor & DNA-binding protein
- one of several proteins that bind to same octamer DNA sequence
- binds to the octamer motif 5'-ATTTGCAT-3' & activates promoters of genes for some small nuclear RNAs (snRNA) & of genes such as those for histone H2B & immunoglobulins
- modulates transcription transactivation by NR3C1, AR & PGR (putative)
- interacts with NR3C1, AR, PGR & HCFC1
- phosphorylated by PRKDC
Structure:
- belongs to the POU transcription factor family, class- 2 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment: nucleus
Alternative splicing: named isoforms=4
Expression:
- ubiquitous in mammalian cells
- isoform 2 is lymphocyte-specific
General
octamer transcription factor
phosphoprotein
Properties
SIZE: entity length = 743 aa
MW = 76 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T270}
POU domain
SITE: 280-354
MOTIF: Ser phosphorylation site {S283}
Ser phosphorylation site {S335}
homeodomain
SITE: 379-438
MOTIF: Ser phosphorylation site {S385}
Ser phosphorylation site {S447}
Ser phosphorylation site {S448}
Database Correlations
OMIM 164175
UniProt P14859
PFAM correlations
Entrez Gene 5451
Kegg hsa:5451
References
- UniProt :accession P14859
- Alberts et al Molecular Biology of the Cell,
2nd ed. 1989, pg 566