K+ sparing diuretic

Indications: - treatment of hypertension - weak blood pressure lowering effects in most patients - adjunctive treatment of heart failure Monitor: - serum K⁺ Drug interactions: - hyperkalemia potentiated by concomitant use of a) ACE inhibitors b) NSAIDs Mechanism of action: - site of action: distal tubule & collecting duct

Interactions

drug interactions drug adverse effects (more general classes) monitor with potassium-sparing diuretics

Specific

amiloride (Midamor, Amipramidin, Modamide) epleronone (Inspra) spironolactone (Aldactone) triamterene (Dyrenium)

References

- Prescriber's Letter 16(2): 2008 Comparison of Commonly Used Diuretics Detail-Document#: 250214 (subscription needed) http://www.prescribersletter.com