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POT1 protein (protection of telomeres 1, POT1-like telomere end-binding protein)
Function:
1) putative telomere end binding protein involved in telomere stability & maintenance
2) component of the telomerase ribonucleoprotein complex
3) component of the double-stranded telomeric DNA-binding TRF1 complex
4) acts as a single-stranded telomeric DNA-binding protein
a) binds 2 or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand)
b) specifically binds a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence
c) binds telomeric single-stranded sequences internally or at proximity of a 3'end
5) activity is TERT dependent
6) does not increase TERT activity
7) binds single-stranded telomeric DNA as a monomer
8) bound in a complex with TERF1, TINF2 & TNKS1
9) interacts with TNKS1
Structure: homodimer or homooligomer
Compartment: nuclear; colocalizes with telomeric DNA
Expression: ubiquitous
General
telomeric repeat binding factor
Properties
SIZE: MW = 71 kD
entity length = 634 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
Database Correlations
OMIM 606478
UniProt Q9NUX5
Pfam PF02765
Entrez Gene 25913
References
- Baumann P & Cech TR.
Pot1, the putative telomere end-binding protein in fission
yeast and humans.
Science 292:1171-5 2001
PMID: 11349150
- UniProt :accession Q9NUX5
Component-of
shelterin complex (telosome)