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posterior cortical atrophy
Etiology:
- Alzheimer's disease
- Lewy body dementia
Pathology:
- degeneration of posterior cortical areas of the brain
- aggregation of Abeta42 & MAP-tau as seen in Alzheimer's disease
Clinical manifestations:
- problems with visuospatial processing
- may be not amnestic manifestations
Notes:
- considered a subtype of Alzheimer's disease (2nd most common presentation)
General
Alzheimer's disease (AD)
References
- Geriatric Review Syllabus, 10th edition (GRS10)
Harper GM, Lyons WL, Potter JF (eds)
American Geriatrics Society, 2019
- Schott JM, Crutch SJ.
Posterior Cortical Atrophy.
Continuum (Minneap Minn). 2019 Feb;25(1):52-75.
PMID: 30707187
- Crutch SJ, Schott JM, Rabinovici GD et al
Consensus classification of posterior cortical atrophy.
Alzheimers Dement. 2017 Aug;13(8):870-884.
PMID: 28259709 Free PMC Article