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post transfusion purpura

Etiology: - blood transfusion or platelet transfusion Epidemiology: - rare Pathology: - alloimmune thrombocytopenia - patients own & donor platelets destroyed - occurs in some patients lacking the PLA-1 platelet antigen Clinical manifestations: - occurs 2-7 [1] or 5-12 [2] days after blood transfusion or platelet transfusion Management: - intravenous immunoglobulin - glucocorticoids - plasmapheresis

General

purpura; retiform purpura

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 591
  2. Wikipedia: Post-transfusion purpura http://en.wikipedia.org/wiki/Post-transfusion_purpura
  3. Gonzalez CE, Pengetze YM. Post-transfusion purpura. Curr Hematol Rep. 2005 Mar;4(2):154-9. PMID: 15720966