Search
post-splicing multiprotein complex
Function:
1) mRNA nuclear export
2) mRNA surveillance
Structure:
- subunits: NXF1, RBM8A, RENT1, RENT2, RENT3A, RENT3B, RNPS1
General
molecular complex
Properties
SUBUNITS: nuclear RNA export factor 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: ALYREF/THOC4 interaction {2-371}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
nuclear translocation signal {67-100}
nuclear export signal {83-110}
RNP motif
NAME: RNP motif
SITE: 119-198
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
leucine-rich repeat
SITE: 266-291
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 292-315
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 316-343
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 344-371
MOTIF: leucine residue (SEVERAL)
NTF2 {386-536}
proline-rich region
SITE: 551-561
MOTIF: proline residue (SEVERAL)
TAP-C {565-619}
RNA-binding protein 8A
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S42}
Ser phosphorylation site {S46}
Ser phosphorylation site {S56}
RNP motif
NAME: RNP motif
SITE: 73-151
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Ser phosphorylation site {S166}
Ser phosphorylation site {S168}
regulator of nonsense transcripts 1
COMPARTMENT: cytoplasm
MOTIF: Sufficient for interaction with RENT2 {1-415}
MOTIF: proline-rich region
SITE: 47-80
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 131-159
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 183-213
EFFECTOR-BOUND: Zn+2
ATP-binding site
NAME: ATP-binding site
SITE: 503-510
serine-rich region {1042-1129}
MOTIF: serine residue (SEVERAL)
Q motif {1089-1090}
Ser phosphorylation site {S1089}
Q motif {1107-1108}
Ser phosphorylation site {S1107}
Ser phosphorylation site {S1127}
regulator of nonsense transcripts 2
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: lysine-rich region {6-136}
MOTIF: lysine residue (SEVERAL)
coiled coil {54-134}
binding site
SITE: 94-133
FOR-BINDING-OF: regulator of nonsense transcripts 1
MIF4G 1 {168-431}
coiled coil {487-559}
MIF4G 2 {569-758}
binding site
SITE: 711-928
FOR-BINDING-OF: regulator of nonsense transcripts 3A
regulator of nonsense transcripts 3B
binding site
SITE: 757-1272
FOR-BINDING-OF: eukaryotic initiation factor 4A1
eukaryotic translation initiation factor 1
MOTIF: MIF4G 3 {773-986}
binding site
SITE: 839-859
FOR-BINDING-OF: regulator of nonsense transcripts 3B
glutamate-rich region {1025-1094}
MOTIF: glutamate residue (SEVERAL)
binding site
SITE: 1084-1272
FOR-BINDING-OF: regulator of nonsense transcripts 1
regulator of nonsense transcripts 3A
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S68}
regulator of nonsense transcripts 3B
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: binding site
SITE: 30-255
FOR-BINDING-OF: regulator of nonsense transcripts 2
MOTIF: binding site
SITE: 52-57
FOR-BINDING-OF: regulator of nonsense transcripts 2
binding site
SITE: 430-447
FOR-BINDING-OF: RNA-binding protein 8A
NMD
RNA-binding protein with serine-rich domain 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: domain {1-220}
MOTIF: domain {1-161}
lysine-rich region {7-64}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S27}
Ser phosphorylation site {S53}
serine-rich region {67-141}
MOTIF: serine residue (SEVERAL)
domain {69-121}
Ser phosphorylation site {S125}
arginine-rich region {128-154}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S155}
domain {156-242}
MOTIF: Ser phosphorylation site {S157}
RNP motif
NAME: RNP motif
SITE: 161-240
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Tyr phosphorylation site {Y205}
domain {238-305}
MOTIF: proline-rich region
SITE: 241-298
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S251}
Ser phosphorylation site {S266}
Ser phosphorylation site {S287}
Ser phosphorylation site {S289}
References
UniProt :accession Q9ULM6
Components
nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP (NXF1, TAP)
regulator of nonsense transcripts 1 (nonsense mRNA reducing factor 1, NORF1, up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1)
regulator of nonsense transcripts 2 (nonsense mRNA reducing factor 2, up-frameshift suppressor 2 homolog, hUpf2, UPF2, KIAA1408, RENT2)
regulator of nonsense transcripts 3A (nonsense mRNA reducing factor 3A, up-frameshift suppressor homolog 3A, hUpf3, UPF3A, RENT3A, UPF3)
regulator of nonsense transcripts 3B (nonsense mRNA reducing factor 3B, up-frameshift suppressor homolog 3B, hUpf3B, hUpf3p-X, UPF3B, RENT3B, UPF3X)
RNA-binding protein 8A; RNA-binding motif protein 8A; ribonucleoprotein RBM8A; RNA-binding protein Y14; binder of OVCA1-1; BOV-1 (RBM8A, RBM8, HSPC114, MDS014)
RNA-binding protein with serine-rich domain 1; SR-related protein LDC2 (RNPS1, LDC2)