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Porphyromonas gingivalis
Pathology:
- etiologic agent of bacterial plaque & adult periodontitis
- identified in the brains of patients with Alzheimer's disease [2]
- produces toxic proteases called gingipains* also identified in the brains of patients with Alzheimer's disease [2]
Pharmacology:
- inhibitors of gingipains* suggested to play a mitigating role in Alzheimer pathology [2]
Related
periodontitis
General
Porphyromonas
Properties
KINGDOM: monera
DIVISION: SCHIZOMYCETES
References
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 185
- Dominy SS, Lynch C, Ermini F et al
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence
for disease causation and treatment with small-molecule inhibitors.
Science Advances 23 Jan 2019: Vol. 5, no. 1, eaau3333
http://advances.sciencemag.org/content/5/1/eaau3333.full