protein-cysteine N-palmitoyltransferase porcupine (protein MG61, PORCN, MG61, PORC, PPN)

Function: - modulates the processing of Wnt proteins - probable protein-cysteine N-palmitoyltransferase that palmitoylates WNT family members - interacts with WNT1, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A & WNT7B (putative) Structure: - belongs to the membrane-bound acyltransferase family, porcupine subfamily Compartment: endoplasmic reticulum membrane Alternative splicing: named isoforms=4 Expression: - isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle & testis - isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis - isoforms 2 & 3 are expressed in substantia negra, spinal cord, heart & lung Pathology: - variants in PORCN at Xp11.23 associated with focal dermal hypoplasia

General

S-palmitoyl transferase transmembrane 8 protein

Properties

SIZE: MW = 52 kD entity length = 461 aa COMPARTMENT: endoplasmic reticulum MOTIF: cytoplasmic domain {1-17} transmembrane domain {18-38} exoplasmic loop {39-66} transmembrane domain {67-87} cytoplasmic loop {88-95} transmembrane domain {96-116} exoplasmic loop {117-152} transmembrane domain {153-173} cytoplasmic loop {174-198} transmembrane domain {199-219} exoplasmic loop {220-252} transmembrane domain {253-273} cytoplasmic loop {274-337} transmembrane domain {338-358} MOTIF: histidine residue {H341} exoplasmic loop {359-396} transmembrane domain {397-417} cytoplasmic domain {418-461}

Database Correlations

UniProt Q9H237 Pfam PF03062

References

UniProt :accession Q9H237