pro-opiomelanocortin; corticotropin-lipotropin (POMC)

Function: - precursor for several anterior pituitary hormones a) ACTH stimulates the adrenal glands to release cortisol b) MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes c) beta-endorphin & Met-enkephalin are endogenous opiates - specific enzymatic cleavages at paired basic residues yield the different active peptides - O-glycosylated - reducing sugar is probably N-acetylgalactosamine Structure: belongs to the POMC family Compartment: secreted Expression: - ACTH & MSH are produced by the pituitary gland Pathology: - PMOC deficiency may be associated with susceptibility to obesity

Related

adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH) corticotropin-like intermediary peptide (CLIP) lipotrophic hormone or lipotropin melanocyte-stimulating hormone (MSH) pro-opiomelanocortin [POMC] gene

General

peptide precursor protein precursor

Properties

SIZE: entity length = 267 aa MW = 29 kD COMPARTMENT: intracellular vesicle CELL: neuron WITHIN: anterior pituitary MOTIF: signal sequence {1-26} cysteine residue {C28} MODIFICATION: cysteine residue {C50} cysteine residue {C50} MODIFICATION: cysteine residue {C28} Thr glycosylation site {T71} N-glycosylation site {N91} Ser phosphorylation site {S168} PRECURSOR-FOR: adrenocorticotropic hormone COMPARTMENT: plasma MOTIF: proteolytic site PRECURSOR-FOR: alpha melanocyte-stimulating hormone (alpha-MSH) COMPARTMENT: extracellular compartment corticotropin-like intermediary peptide (CLIP) COMPARTMENT: extracellular compartment beta-lipotrophic hormone MOTIF: proteolytic site PRECURSOR-FOR: gamma-lipotrophic hormone MOTIF: proteolytic site PRECURSOR-FOR: beta melanocyte-stimulating hormone (beta-MSH) COMPARTMENT: extracellular compartment beta-endorphin COMPARTMENT: plasma MOTIF: proteolytic site (SEVERAL) N-glycosylation site {N127} N-glycosylation site {N152} PRECURSOR-FOR: enkephalin COMPARTMENT: extracellular compartment alpha melanocyte-stimulating hormone (alpha-MSH) COMPARTMENT: extracellular compartment gamma melanocyte-stimulating hormone (gamma-MSH) COMPARTMENT: extracellular compartment beta-endorphin COMPARTMENT: plasma MOTIF: proteolytic site (SEVERAL) N-glycosylation site {N127} N-glycosylation site {N152} PRECURSOR-FOR: enkephalin COMPARTMENT: extracellular compartment beta melanocyte-stimulating hormone (beta-MSH) COMPARTMENT: extracellular compartment gamma-lipotrophic hormone MOTIF: proteolytic site PRECURSOR-FOR: beta melanocyte-stimulating hormone (beta-MSH) COMPARTMENT: extracellular compartment methionine enkephalin COMPARTMENT: extracellular compartment

Database Correlations

OMIM correlations MORBIDMAP 176830 UniProt P01189 PFAM correlations Entrez Gene 5443 Kegg hsa:5443