nuclear envelope pore membrane protein POM 121; pore membrane protein of 121 kDa; nuclear envelope pore membrane protein POM 121A (POM121 KIAA0618 NUP121 POM121A)

Function: - component of the nuclear pore complex - repeat-containing domain may be involved in anchoring components of the nuclear pore complex to the pore membrane - when overexpressed in cells induces the formation of cytoplasmic annulate lamellae Structure: - belongs to the POM121 family - contains F-X-F-G repeats Compartment: - nuclear pore complex, endoplasmic reticulum membrane - stably associated with the nuclear pore complex throughout interphase & endoplasmic reticulum during metaphase Alternative splicing: named isoforms=3

General

membrane protein nucleoporin (nuclear pore complex protein)

Properties

SIZE: entity length = 1249 aa MW = 128 kD COMPARTMENT: cell nucleus endoplasmic reticulum MOTIF: nuclear targeting {1-285} MOTIF: Cisternal side {1-34} transmembrane domain {35-55} Pore side {56-1249} MOTIF: proline-rich region SITE: 144-214 MOTIF: proline residue (SEVERAL) serine-rich region {378-445} MOTIF: serine residue (SEVERAL) threonine-rich region {751-947} MOTIF: threonine residue (SEVERAL)

Database Correlations

UniProt Q96HA1 Kegg hsa:9883

References

UniProt :accession Q96HA1