Contents

Search

polynucleotide kinase (PNK)

Function: - possesses 3' DNA phosphatase & 5' DNA kinase activity - both activities stimulated by XRCC1 at damaged DNA termini - XRCC1, polynucleotide kinase, DNA ligase III & DNA polymerase beta associate in a multiprotein complex

General

kinase or ATP-phosphotransferase

Properties

SIZE: MW = 57.1 kD entity length = 521 aa MOTIF: kinase domain MOTIF: ATP-binding site NAME: ATP-binding site

References

  1. Whitehouse CJ et al XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell 104:107-17 2001 PMID: 11163244
  2. OMIM :accession 605610

Databases & Figures

OMIM 605610 Mechanism of base excision repair (v.2)