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polymixin B (Aerosporin)
Tradename: Aerosporin.
Indications:
- bacterial infections due to susceptible organisms
- topical application only
- lower urinary tract infections due to resistant gram negative bacilli, including carbapenem-resistant
- Enterobacteriaceae
- Pseudomonas aeruginosa
- Acinetobacter baumannii [2]
- otitis externa [4]
Antimicrobial activity:
- Gram negative
- Pseudomonas aeruginosa
- Klebsiella species
- Escherichia coli
- Haemophilus influenzae [4]
* No gram-positive or anti-fungal activity
Dosage:
- bladder irrigation 250,000 units in 1 liter of normal saline continuously over 24 hours
Pharmacokinetics: topical use only
Adverse effects:
1) allergic reactions
2) bladder irritation
Mechanism of action:
1) bactericidal
2) binds to phosphate groups in the lipids of bacterial cytoplasmic membranes causing membrane instability & leakage
3) resistance is rare
Notes:
- mcr-1 testing of all Enterobacteriaceae isolates with a colistin or polymyxin B minimum inhibitory concentration of 4 ug/mL or higher [5]
- testing can be performed through the CDC
Interactions
drug interactions
General
polymixin
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 6 HOUR
Database Correlations
PUBCHEM correlations
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Medical Knowledge Self Assessment Program (MKSAP) 16,
American College of Physicians, Philadelphia 2012
- Chen LF, Kaye D.
Current use for old antibacterial agents: polymyxins,
rifamycins, and aminoglycosides.
Infect Dis Clin North Am. 2009 Dec;23(4):1053-75,
PMID: 19909897
- Deprecated Reference
- Orciari Herman A, Sadoughi S, Sofair A.
CDC: E. Coli Resistant to Last-Resort Antibiotic Again Found
in U.S., No Transmission Seen
Physician's First Watch, Sept 12, 2016
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
Component-of
bacitracin/cortisol/neomycin/polymixin b
bacitracin/lidocaine/neomycin/polymixin b
bacitracin/neomycin/polymixin b/pramoxine
bacitracin/neomycin/polymixin-B (Neosporin)
bacitracin/polymixin-B (Polysporin, Ocumycin)
cortisol/neomycin/polymixin-B (Corticosporin, Cortisporin, Cortomycin)
cortisol/neomycin/polymyxin B
cortisol/polymixin b
dexamethasone/neomycin/polymixin-B (Maxitrol, Dexasporin)
gramicidin/neomycin/polymixin-B (Opthneosporin, AK-spore)
miconazole/nitrate/polymixin b/prednisolone
Neomycin/Polymixin B (Neosporin GU irrigant)
neomycin/polymixin B/pramoxine
neomycin/polymixin b/prednisolone
oxytetracycline/polymixin b
polymixin-B/trimethoprim (Polytrim)