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polymerase proofreading-associated polyposis
Pathology:
- features of both adenomatous polyposis coli (FAP) & Lynch syndrome
- associated with endmetrial cancer
- microsatellite instability
Genetics:
- autosomal dominant
- associated with defects DNA polymerase proofreading genes POLE & POLD1
Management:
- guidelines not yet established
- follow guidelines for colorectal polyps
General
adenomatous polyposis syndrome
References
- Medical Knowledge Self Assessment Program (MKSAP) 18.
American College of Physicians, Philadelphia 2018.