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polygenic risk score
Presumptively genetic profiling for cardiometabolic diseases
- coronary artery disease
- hypercholesterolemia
- type 2 diabetes
- atrial fibrillation
- venous thromboembolic disease & response to drug therapy [1]
Disadvantages:
- inferior to coronary artery calcium score [2]
General
cardiac risk assessment
References
- O'Sullivan JW, Raghavan S, Marquez-Luna C et al
Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association.
Circulation. 2022 Aug 23;146(8):e93-e118.
PMID: 35862132 PMCID: PMC9847481 (available on 2023-08-23)
https://jamanetwork.com/journals/jama/fullarticle/2805138
- Khan SS et al.
Coronary artery calcium score and polygenic risk score for the prediction of
coronary heart disease events.
JAMA 2023 May 23; 329:1768.
PMID: 37219552 PMCID: PMC10208141 (available on 2023-11-23)
https://jamanetwork.com/journals/jama/fullarticle/2805138