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RNA polymerase 2 140 kD subunit (RPB2, RNA polymerase 2 subunit B, RNA polymerase 2 subunit 2, POLR2B)
Function:
- 2nd largest subunit of RNA polymerase 2
- forms the polymerase active center together with POLR2A
- initial binding of ribonucleoside triphosphates seems to occur at the entry (E) site & involves a Mg+2 coordinated by 3 conserved Asp of the two largest RNA polymerase 2 subunits, POLR2A & POLR2B (putative)
Structure: belongs to the RNA polymerase beta chain family
Compartment: nucleus
General
RNA polymerase L
zinc finger protein
Properties
SIZE: entity length = 1174 aa
MW = 134 kD
COMPARTMENT: cell nucleus
MOTIF: Mg+2-binding site
SITE: 792-792
Zn finger C4-type
SITE: 1119-1140
EFFECTOR-BOUND: Zn+2
MOTIF: Zn+2-binding site
SITE: 1119-1119
Zn+2-binding site
SITE: 1122-1122
Zn+2-binding site
SITE: 1137-1137
Zn+2-binding site
SITE: 1140-1140
Database Correlations
OMIM 180661
UniProt P30876
PFAM correlations
Kegg hsa:5431
ENZYME 2.7.7.6
References
- UniProt :accession P30876
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 266
Component-of
RNA polymerase-2