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DNA polymerase epsilon catalytic subunit (subunit A, subunit 1, POLE, POLE1)
Function:
- role in DNA repair & in chromosomal DNA replication
- interacts with RAD17 & TOPBP1
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- DNA polymerase activity domain resides in the N-terminal half of the protein
- the C-terminus is necessary for complexing subunits B & C
- C-terminus may also regulate catalytic activity
- belongs to the DNA polymerase type-B family
Compartment: nucleus
General
phosphoprotein
protein subunit
zinc finger protein
Properties
SIZE: entity length = 2286 aa
MW = 262 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S1940}
Zn finger C4-type
SITE: 2158-2190
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 2221-2238
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 174762
UniProt Q07864
PFAM correlations
Kegg hsa:5426
ENZYME 2.7.7.7
References
- UniProt :accession Q07864
- Linn S
How many pols does it take to replicate nuclear DNA?
Cell 66:185 1991
PMID: 1855251
Component-of
DNA polymerase epsilon