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dexchlorpheniramine (Polaramine)
Tradename: Polaramine. (dexchlorpheniramine maleate)
Indications:
1) treatment of allergic reactions
- allergic conjunctivitis, atopy [2]
2) treatment of cold symptoms
- nasal congestion, rhinorrhea, sneezing [2]
2) urticaria, pruritus
Contraindications:
1) narrow-angle glaucoma
2) bladder neck obstruction
3) symptomatic prostatic hypertrophy
4) asthmatic attack
5) stenosing peptic ulcer
Dosage:
1) adults & children > 12 years:
a) 4-6 mg QHS (timed-release)
b) 4-6 mg every 8-10 hours (timed release)
2) children 6-11 years: 4 mg QHS (timed release)
Tabs: (sustained-release): 4 & 6 mg.
Pharmacokinetics: (see chlorpheniramine)
Adverse effects:
1) common (> 10%)
1) slight to moderate drowsiness
2) thickening of bronchial secretions
2) less common (1-10%)
- headache, fatigue, appetite increase, weight increase, nervousness, dizziness, nausea, diarrhea, abdominal pain, dry mouth, pharyngitis, arthralgia
3) uncommon (< 1%)
- angioedema, bronchospasm, depression, edema, epistaxis, hepatitis, myalgia, palpitations, paresthesias, photosensitivity, rash
Drug interactions: (see chlorpheniramine)
Mechanism of action: histamine H1 receptor antagonist
Interactions
drug adverse effects (more general classes)
General
chlorpheniramine (Chlor-Trimeton)
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 12-40 HOURS
pregnancy-category B
safety in lactation -
Database Correlations
PUBCHEM correlations
References
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
Component-of
acetaminophen/dexchlorpheniramine/pseudoephedrine
carbetapentane/citrate/dexchlorpheniramine/phenylephrine
carbetapentane/dexchlorpheniramine/phenylephrine
chlophedianol/dexchlorpheniramine/pseudoephedrine
codeine/dexchlorpheniramine/phenylephrine
codeine/dexchlorpheniramine/phenylephrine/phosphate
dexchlorpheniramine/dextromethorphan/guaifenesin/phenylephrine
dexchlorpheniramine/dextromethorphan/phenylephrine
dexchlorpheniramine/dextromethorphan/phenylephrine/pyrilamine
dexchlorpheniramine/dextromethorphan/pseudoephedrine
dexchlorpheniramine/guaifenesin/pseudoephedrine
dexchlorpheniramine/hydrocodone/phenylephrine
dexchlorpheniramine/methscopolamine/phenylephrine
dexchlorpheniramine/methscopolamine/pseudoephedrine
dexchlorpheniramine/phenylephrine
dexchlorpheniramine/pseudoephedrine
dexchlorpheniramine/pseudoephedrine/pyrilamine