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POEMS trial

Study characteristics: - 200 premenopausal women with hormone-receptor-negative breast cancer Treatment: - chemotherapy with or without monthly injections of goserelin, a gonadotropin-releasing hormone agonist. Results: - 2-year premature ovarian failure rate was lower in the goserelin arm (8% vs. 22%) - more pregnancies occurred in the goserelin group

General

clinical trial

References

  1. Moore HC et al Phase III trial (Prevention of Early Menopause Study [POEMS]- SWOG S0230) of LHRH analog during chemotherapy (CT) to reduce ovarian failure in early-stage, hormone receptor-negative breast cancer: An international Intergroup trial of SWOG, IBCSG, ECOG, and CALGB (Alliance). J Clin Oncol 32:5s, 2014 (suppl; abstr LBA505) http://abstracts.asco.org/144/AbstView_144_129172.html