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5-phosphomevalonate kinase (PMVK)
Function:
- role in cholesterol biosynthesis
- role in isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonate pathway; isopentenyl-PP from R-mevalonate: step 2/3
ATP + (R)-5-phosphomevalonate
ADP + (R)-mevalonate-5-pyrophosphate
Structure: monomer (putative)
Compartment: peroxisome
Expression:
- expressed in heart, liver, skeletal muscle, kidney, & pancreas > brain, placenta, & lung
- induced by sterol
Pathology:
- point mutations associated with linear porokeratosis
Interactions
molecular events
Related
cholesterol biosynthesis
General
kinase or ATP-phosphotransferase
Properties
COMPARTMENT: cytoplasm
MOTIF: kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
UniProt Q15126
ENZYME 2.7.4.2
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 442
- UniProt :accession Q15126