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PML-RAR alpha fusion protein

product of translocation t(15;17)(q21;q21), seen in some cases of acute promyelocytic leukemia. represses transcription by associating with a corepressor complex containing histone deacetylase activity [1]

General

protein product of a chromosomal translocation

References

  1. Marks et al. Nature Reviews Cancer 1:194-202, 2001