Search
PML NB complex
Complex with exonuclease activity involved in antiviral function of IFN against RNA viruses (see ISG20)
Structure:
- consists of at least
a) ISG20
b) transcription factor PML
c) SP100
General
molecular complex
Properties
SUBUNITS: interferon-stimulated gene 20 kD protein
COMPARTMENT: cell nucleus
MOTIF: active site
transcription factor PML
MOTIF: proline-rich region
SITE: 3-46
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S8}
RING-finger {57-92}
MOTIF: Zn+2-binding site
SITE: 57-57
Zn+2-binding site
SITE: 60-60
Zn+2-binding site
SITE: 72-72
Zn+2-binding site
SITE: 74-74
Zn+2-binding site
SITE: 77-77
Zn+2-binding site
SITE: 80-80
Zn+2-binding site
SITE: 88-88
Zn+2-binding site
SITE: 91-91
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 124-166
EFFECTOR-BOUND: Zn+2
zinc finger B box
SITE: 183-236
EFFECTOR-BOUND: Zn+2
coiled coil {228-253}
Breakpoint {394-395}
Ser phosphorylation site {S403}
nuclear translocation signal {476-490}
Ser phosphorylation site {S504}
Ser phosphorylation site {S505}
Ser phosphorylation site {S512}
Ser phosphorylation site {S518}
Ser phosphorylation site {S527}
Ser phosphorylation site {S530}
Ser phosphorylation site {S535}
Breakpoint {552-553}
Ser phosphorylation site {S560}
Ser phosphorylation site {S561}
Ser phosphorylation site {S562}
Ser phosphorylation site {S565}
nuclear autoantigen Sp-100
COMPARTMENT: cell nucleus
MOTIF: glycine-rich region {3-6}
Ser phosphorylation site {S18}
HSR {33-149}
glutamate-rich region {156-164}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S157}
peptide motif {284-297}
Ser phosphorylation site {S327}
Ser phosphorylation site {S328}
Ser phosphorylation site {S331}
Ser phosphorylation site {S334}
Thr phosphorylation site {T335}
Ser phosphorylation site {S407}
Ser phosphorylation site {S409}
Ser phosphorylation site {S410}
Ser phosphorylation site {S451}
Ser phosphorylation site {S452}
Ser phosphorylation site {S453}
Ser phosphorylation site {S456}
Ser phosphorylation site {S459}
nuclear translocation signal {536-553}
nuclear translocation signal {568-592}
SAND {595-676}
HMG box
SITE: 677-753
MOTIF: nuclear translocation signal {717-734}
lysine-rich region {759-764}
MOTIF: lysine residue (SEVERAL)
HMG box
SITE: 769-837
lysine-rich region {854-859}
MOTIF: lysine residue (SEVERAL)
glutamate-rich region {860-868}
MOTIF: glutamate residue (SEVERAL)
References
UniProt :accession Q14626
Components
interferon-stimulated gene 20 kD protein; estrogen-regulated transcript 45 protein; promyelocytic leukemia nuclear body-associated protein ISG20 (ISG20, HEM45)
nuclear autoantigen Sp-100; nuclear dot-associated Sp100 protein; speckled 100 kDa; Lysp100b (SP100)
transcription factor PML; tripartite motif-containing protein 19; RING finger protein 71 (PML, MYL, RNF71, TRIM19)