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phospholipid scramblase 4; PL scramblase 4; Ca+2-dependent phospholipid scramblase 4; cell growth-inhibiting gene 43 protein; TRA1 (PLSCR4)
Function:
- may facilitate ATP-independent bidirectional transbilayer migration of phospholipids upon binding Ca+2, resulting in a loss of phospholipid asymmetry in the plasma membrane
- role in the initiation of fibrin clot formation
- role in activation of mast cells
- role in recognition of apoptotic & injured cells by the reticuloendothelial system
- interacts with PDCD6
Cofactor: Ca+2 (putative)
Structure:
- belongs to the phospholipid scramblase family
Compartment:
- membrane; single-pass type 2 membrane protein (putative)
Expression:
- expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine & colon
- not expressed in peripheral blood lymphocytes
General
phospholipid scramblase 2; PL scramblase; Ca2+ dependent phospholipid scramblase
Properties
SIZE: entity length = 329 aa
MW = 37 kD
COMPARTMENT: cellular membrane
MOTIF: SH3-binding site
NAME: SH3-binding site
SITE: 18-25
WW-binding {30-33}
SH3-binding site
NAME: SH3-binding site
SITE: 41-49
Tyr phosphorylation site {Y83}
Tyr phosphorylation site {Y88}
SH3-binding site
NAME: SH3-binding site
SITE: 98-106
cysteine-rich region {195-202}
cysteine residue {C250}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C255}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {304-320}
Database Correlations
OMIM 607612
UniProt Q9NRQ2
Pfam PF03803
Entrez Gene 57088
Kegg hsa:57088
References
UniProt :accession Q9NRQ2