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phospholipid scramblase 3; PL scramblase 3; Ca+2-dependent phospholipid scramblase 3 (PLSCR3)
Function:
- may facilitate ATP-independent bidirectional transbilayer migration of phospholipids upon binding Ca+2, resulting in a loss of phospholipid asymmetry in the plasma membrane
- role in the initiation of fibrin clot formation (putative)
- role in activation of mast cells (putative)
- role in recognition of apoptotic & injured cells by the reticuloendothelial system (putative)
- interacts with PDCD6 (Ca+2-dependent)
Cofactor: Ca+2 (putative)
Structure:
- belongs to the phospholipid scramblase family
Compartment:
- membrane; single-pass type 2 membrane protein (putative)
Expression:
- expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine & peripheral blood lymphocytes
- not expressed in testis, brain & liver
General
phospholipid scramblase 2; PL scramblase; Ca2+ dependent phospholipid scramblase
Properties
SIZE: entity length = 295 aa
MW = 32 kD
COMPARTMENT: cellular membrane
MOTIF: SH3-binding site
NAME: SH3-binding site
SITE: 7-15
proline-rich region
SITE: 12-19
MOTIF: proline residue (SEVERAL)
WW-binding {15-18}
SH3-binding site
NAME: SH3-binding site
SITE: 21-27
SH3-binding site
NAME: SH3-binding site
SITE: 65-70
cysteine-rich region {158-165}
cysteine residue {C211}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C214}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C216}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {266-282}
Database Correlations
OMIM 607611
UniProt Q9NRY6
Pfam PF03803
Entrez Gene 57048
Kegg hsa:57048
References
UniProt :accession Q9NRY6