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ploidy measurement; somatic copy number alterations (SCNA)

Clinical significance: - may be prognostic markers for range of different cancers - neoplastic cells may be polyploid or aneuploid - tumor aneuploidy correlates with markers of immune evasion & with reduced response to immunotherapy [1]

Related

alpha synuclein (SCNA) gene ploidy

General

cytogenetics

References

  1. Kerr DJ Overlooked Biomarker May Predict Cancer Immunotherapy Response. Medscaape. Feb 15, 2018 https://www.medscape.com/viewarticle/892475 - Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017 Jan 20;355(6322) pii: eaaf8399 PMID: 28104840 Free PMC Article