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lipid storage droplet protein 5 (LSDP5, PLIN5)

Function: - binds to lipid droplets & protects them from lipolytic degradation - enhances mitochondrial biogenesis & function - fatty-acid-binding protein - preferentially binds lipid droplet-derived monounsaturated fatty acids & traffics them to the nucleus following cAMP/PKA-mediated lipolytic stimulation Structure: belongs to the perilipin family Compartment: - lipid droplet, surface-associated Alternative splicing: named isoforms=2 Expression: - expressed in skeletal muscle, liver, heart & kidney

General

perilipin; lipid droplet-associated protein (PLIN)

Properties

SIZE: entity length = 463 aa MW = 51 kD

Database Correlations

UniProt Q00G26 Pfam PF03036

References

  1. UniProt :accession Q00G26
  2. Najt CP, Khan SA, Heden TD et al Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1. Mol Cell. 2020 Feb 20;77(4):810-824.e8. doi: 10.1016/j.molcel.2019.12.003. Epub 2019 Dec 31. PMID: 31901447