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platelet aggregation; platelet function

Pathology: - following vascular injury, platelets rapidly adhere to the exposed endothelium in conjunction with von Willebrand factor (vWF) which serves as a 'glue' connecting subendothelial collagen to platelets via platelet cell surface glycoprotein 1b/V IX receptor complex Pharmacology: - effects of aspirin on platelets are irreversible - effects of other NSAIDs on platelets are reversible Laboratory: - see platelet aggregation measurement

Related

platelet platelet aggregation measurement; platelet function analysis (PFA-100) platelet glycoprotein 1b von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)

Specific

platelet aggregation ristocetin inhibitor

General

EVENT

References

  1. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 702-703
  2. Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
  3. Favaloro EJ, Lippi G, Franchini M. Contemporary platelet function testing. Clin Chem Lab Med. 2010 May;48(5):579-98 PMID: 20148722