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platelet-activating factor (PAF)

Platelet activating factor (PAF) causes increased vascular permeability, neutrophil aggregation & activation, & platelet activation at low concentrations. At high concentrations, PAF induces vasoconstriction & bronchoconstriction.

Related

platelet platelet-activating factor receptor; PAF-R (PTAFR PAFR)

General

autocrine hormone paracrine hormone plasmalogen

Properties

COMPARTMENT: cellular membrane SECRETED-BY: basophil mast cell neutrophil monocyte macrophage endothelial cell platelet

Database Correlations

PUBCHEM correlations

References

  1. Barnes PJ. Molecular biology. Inflammatory activities. Nature. 1991 Jan 24;349(6307):284-5. No abstract available. PMID: 1846227
  2. Honda Z, Nakamura M, Miki I, Minami M, Watanabe T, Seyama Y, Okado H, Toh H, Ito K, Miyamoto T, et al. Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung. Nature. 1991 Jan 24;349(6307):342-6. PMID: 1846231
  3. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 58