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platelet 6-phosphofructokinase (phosphofructokinase 1, phosphohexokinase, phosphofructo-1-kinase isozyme C, PFK-C, 6-phosphofructokinase platelet type, PFKP, PFKF)
Function:
- 6 phosphofructokinase is a tetramer in muscle is M4, liver is L4, & red cell is M3L,M2L2, or ML3
- a subunit composition with a higher proportion of platelet type subunits is found in platelets, brain & fibroblasts
- carbohydrate degradation, glycolysis
- D-glyceraldehyde 3-phosphate & glycerone phosphate from D-glucose: step 3/4
- allosteric enzyme activated by ADP, AMP, or fructose bisphosphate & inhibited by ATP or citrate
Cofactor: Mg+2
Structure:
- tetramer
- belongs to the phosphofructokinase family, 2 domains subfamily
General
6-phosphofructo-1-kinase, phosphohexokinase or phosphofructokinase-1
Properties
SIZE: entity length = 784 aa
MW = 86 kD
COMPARTMENT: cytoplasm
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 44-48
aspartate residue {D175}
ATP-binding site
NAME: ATP-binding site
SITE: 202-206
binding site
SITE: 210-210
FOR-BINDING-OF: Substrate
ATP-binding site
NAME: ATP-binding site
SITE: 219-235
MOTIF: Mg+2-binding site
SITE: 233-233
binding site
SITE: 301-301
FOR-BINDING-OF: Substrate
binding site
SITE: 307-307
FOR-BINDING-OF: Substrate
binding site
SITE: 310-310
FOR-BINDING-OF: Substrate
Ser phosphorylation site {S386}
Tyr phosphorylation site {Y651}
Ser phosphorylation site {S783}
Database Correlations
OMIM 171840
UniProt Q01813
KEGG correlations
ENZYME 2.7.1.11
References
UniProt :accession Q01813