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plasminogen activator inhibitor-1 genotyping

Clinical significance: - plasminogen activator inhibitor-1 a) major inhibitor of fibrinolysis b) when increased, fibrinolytic activity is diminished with increased risk of 1] arterial thrombosis 2] venous thrombosis c) increased activity is an independent risk factor for 1] coronary artery disease 2] ischemic stroke 3] venous thrombosis 4] osteonecrosis Specimen: - whole blood

General

genotyping (allele testing)

References

  1. Molecular Diagnostics Laboratory http://www.mdl-labs.com/testing/PAI-1GeneMutation.html
  2. Vaughan DE. PAI-1 and atherothrombosis. J Thromb Haemost. 2005 Aug;3(8):1879-83. PMID: 16102055
  3. Panel of 24 tests Laboratory Test Directory ARUP: 2004980