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plasmin; fibrinolysin
Function:
- plasmin dissolves the fibrin of blood clots & acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, & inflammation
- in ovulation, plasmin weakens the walls of the Graafian follicle
- plasmin activates the urokinase-type plasminogen activator, collagenases & several complement zymogens, such as complement C1 & complement C5
- cleavage of fibronectin & laminin leads to cell detachment & apoptosis
- plasmin also cleaves fibrin, thrombospondin & von Willebrand factor
- role of plasmin in tissue remodeling & tumor invasion may be modulated by CSPG4
- preferential cleavage: Lys-|-Xaa > Arg-|-Xaa
- higher selectivity than trypsin
- converts fibrin into soluble products
- substrates include fibrin & other matrix proteins & amyloid A4 peptide (both monomeric & fibrils in vitro [3]
- plasmin activity inhibited by SERPINE2
- plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from a clot
Expression:
- plasmin is generated on surfaces, either through binding of its precursor plasminogen to fibrin or to the surface of platelets
Interactions
molecular events
Related
complement cascade
fibrin
fibrinolysis
plasminogen; contains: plasmin heavy chain A; activation peptide; angiostatin; plasmin light chain B (PLG)
platelet
Specific
ocriplasmin
General
fibrinolytic agent (thrombolytic agent)
plasma protein
serine protease trypsin family
Properties
SIZE: MW = 88 kD
COMPARTMENT: plasma
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
kringle domain
allosteric site
FOR-BINDING-OF: complement C1 inhibitor
STATE: active state
Database Correlations
UniProt P00747
ENZYME 3.4.21.7
References
- Clinical Diagnosis and Management by Laboratory
Methods, 18th ed, J.B. Henry (ed), W.B. Saunders,
Philadelphia, PA, 1991 pg 739
- Fibrinolysis, Thrombosis, & Hemostasis: Concepts,
Perspectives, and Clinical Applications. S Sherry,
Lea & Febiger, Philadelphia, 1992, pg 15, 81
- Selkoe DJ.
Clearing the brain's amyloid cobwebs.
Neuron. 2001 Oct 25;32(2):177-80. Review.
PMID: 11683988