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hepcidin in serum/plasma
Reference interval:
- nmoles/L
Clinical significance:
- decreases in iron-deficiency
- binding to & induces degradation of ferroportin, which exports iron from cells
- in iron deficiency, transcription of hepcidin is suppressed
- this adaptive mechanism facilitates absorption of iron & release of iron from body stores
Decreases:
- dapagliflozin may decrease plasma hepcidin in patients with diabetes mellitus type 2 [3]
Related
hepcidin antimicrobial peptide; liver-expressed antimicrobial peptide; LEAP-1; putative liver tumor regressor; PLTR [Contains: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)] (HAMP, HEPC, LEAP1, UNQ487/PRO1003)
Specific
pro-hepcidin in serum/plasma
General
special chemistry test
References
- Medical Knowledge Self Assessment Program (MKSAP) 16,
American College of Physicians, Philadelphia 2012
- Rothaus C
Iron-Deficiency Anemia
Now@NEJM
http://blogs.nejm.org/now/index.php/iron-deficiency-anemia/2015/05/08/
- Monaco K
Dapagliflozin Tied to Drop in Hepcidin Levels.
Decrease may boost hematocrit and hemoglobin after SGLT-2
inhibitor therapy.
MedPage Today. May 20, 2018
https://www.medpagetoday.com/meetingcoverage/aace/72989
- Ghanim H, et al
Dapagliflozin Suppresses Plasma Hepcidin Concentrations.
American Association of Clinical Endocrinologists (AACE) 2018;
Abstract 228