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fibrinogen in plasma

Indications: - evaluation of disseminated intravascular coagulation - *evaluation of inflammation (confirmation of elevated ESR) Normal range: 1) adults: 200-400 mg/dL 2) newborn: 125-300 mg/dL Clinical significance: - fibrinogen is an acute phase protein - increased plasma levels are an independent risk factor for coronary artery disease & cerebrovascular disease - fibrinogen is the principal plasma protein affecting the erythrocyte sedimentation rate (ESR) Increases: 1) inflammation (within 24 hours) 2) tissue necrosis 3) estrogens & oral contraceptives Decreases: 1) decreased hepatic synthesis 2) disseminated intravascular coagulation (DIC) 3) anabolic steroids & androgens 4) fish oil 5) plasminogen activators 6) valproic acid 7) afibrinogenemia (rare) Methods: 1) thrombin clotting time of dilute plasma 2) radioimmunodiffusion (RID) 3) total fibrinogen, measured by immunoassay may not correlate with functional fibrinogen in patients with dysfibrinogenemia Specimen: 1) plasma (sodium citrate) 2) stable at -20 degrees C for several months

Related

dysfibrinogenemia fibrinogen; coagulation factor-1

Specific

fibrinogen in plasma interpretation fibrinogen in plasma qualitative

General

special chemistry test

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  2. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  3. Fibrinogen Laboratory Test Directory ARUP: 30130
  4. Panel of 3 tests Laboratory Test Directory ARUP: 30137
  5. Panel of 7 tests Laboratory Test Directory ARUP: 2003947

Component-of

DIC panel fibrinogen Ag/fibrinogen in plasma PT/aPTT/fibrinogen in plasma