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aldosterone in serum/plasma

Indications: - evaluation of hyperaldosteronism Reference interval: 1) supine: 2-5 ng/dL (60-140 pmol/L) 2) standing: 7-20 ng/dL (194-555 pmol/L) [1] * assumes normal sodium intake Increases: 1) primary hyperaldosteronism a) bilateral adrenal hyperplasia b) aldosterone-secreting adrenal adenoma 2) secondary hyperaldosteronism a) laxative abuse b) diuretic abuse c) heart failure d) cirrhosis of the liver with ascites e) nephrotic syndrome f) idiopathic cyclic edema g) Bartter' syndrome h) hypervolemia due to hemorrhage i) renal juxtaglomerular hyperplasia with K+ wastage j) renal hemangiopericytoma producing renin k) malignant hypertension of renal origin l) thermal stress m) pregnancy n) starvation after 10 days o) COPD 3) drugs - angiotensin, estrogens, laxatives, loop diuretics, metoclopramide, oral contraceptives, spironolactone, thiazides, K+, serotonin reuptake inhibitors (SSRI), Decreases: - Liddle syndrome - drugs - aminoglutethimide, licorice, direct renin inhibitors NSAIDs - alpha-adrenergic receptor agonists - beta-adrenergic receptor antagonists [1] - ACE inhibitors, dihydropyridine calcium channel blockers Methods: - see aldosterone in serum/urine Specimen: - plasma (heparin or EDTA) or serum a) store frozen b) stable for 2 years at -20 degrees C in airtight container

Related

aldosterone (Electrocortin, Aldocortin) angiotensin-1/renin activity in plasma renin-angiotensin-aldosterone axis

Specific

aldosterone in serum/plasma standing aldosterone in serum/plasma supine

General

aldosterone in body fluid

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17. American College of Physicians, Philadelphia 1998, 2012, 2015
  2. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  3. Aldosterone Laboratory Test Directory ARUP: 70015
  4. Panel of 3 tests Laboratory Test Directory ARUP: 70073
  5. Panel of 3 tests Laboratory Test Directory ARUP: 2002582

Component-of

aldosterone renal clearance aldosterone+ renin panel in/plasma Aldosterone/Renin in serum/plasma captopril-renin stimulation test fludrocortisone suppression test intravenous salt loading test