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plane xanthoma
Etiology:
- multiple myeloma, paraproteinemia, leukemia, lymphoma
- diffuse (neck, face, upper trunk, arms)
- homozygous familial hypercholesterolemia
- intertriginous areas
- dysbetalipoproteinemia
- palmar xanthomas
Clinical manifestations:
- flat, yellow plaques
- most commonly involve skin folds
- - image of palmar xanthomas [2]
Laboratory:
- lipid panel
a) may be normal with diffuse form associated with lymphoid neoplasm
b) LDL cholesterol elevated with dyslipidemia
c) serum triglycerides may be elevated with dysbetalipoproteinemia
General
xanthoma
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 18.
American College of Physicians, Philadelphia 2009, 2018.
- Koehler VF, Parhofer KG.
Images in Clinical Medicine. Xanthoma Striatum Palmare.
N Engl J Med 2018; 378:e26. May 10, 2018
PMID: 29742369
https://www.nejm.org/doi/full/10.1056/NEJMicm1713658