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catenin gamma; junction plakoglobin; desmoplakin-3 (JUP, CTNNG, DP3)
Function:
- common junctional plaque protein
- membrane-associated plaques are architectural elements in a strategic position to influence the arrangement & function of both the cytoskeleton & the cells within tissue
- presence of gamma catenin in both the desmosomes & in the intermediate junctions suggests that it plays a role in structure & function of submembranous plaques
- interacts with desmoglein 1
- interacts with MUC1
Structure:
- homodimer
- belongs to the beta-catenin family
- contains 9 ARM repeats
Compartment:
- cell junction, adherens junction, desmosome
- cytoplasm, cytoskeleton, peripheral membrane
- cytoplasmic in a soluble & membrane-associated form
Genetics: gene locus: 17q21
Pathology:
- defects in JUP are the cause of
a) Naxos disease
b) arrhythmogenic right ventricular cardiomyopathy type 12
General
beta catenin family protein
catenin
desmoplakin (desmoplakin 1 & desmoplakin 2); 250/210 kD paraneoplastic pemphigus antigen (DSP)
phosphoprotein
Properties
SIZE: entity length = 745 aa
MW = 82 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y20}
ARM repeat {132-171}
Ser phosphorylation site {S182}
ARM repeat {216-255}
ARM repeat {258-297}
ARM repeat {342-381}
ARM repeat {383-420}
ARM repeat {423-464}
ARM repeat {470-510}
ARM repeat {512-551}
ARM repeat {574-613}
Tyr phosphorylation site {Y660}
Ser phosphorylation site {S665}
Database Correlations
OMIM correlations
MORBIDMAP 173325
UniProt P14923
PFAM correlations
References
- UniProt :accession P14923
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=JUP
- Takeichi M.
Cadherin cell adhesion receptors as a morphogenetic regulator.
Science. 1991 Mar 22;251(5000):1451-5. Review.
PMID: 2006419