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placebo effect

Effect of placebo or sham procedure. Notes: - may be a genetic predisposition to respond to placebo [2] - 12% of UK physicians have used placebos [3] - 50% of patients told "this therapy has helped many other patients" - placebo effect of injection > topical placebo > oral placebo [4] - 40% response rate with large effect sizes for needle-based procedures in osteoarthritis [6] (no biologic benefit) - placebo responses may last beyond one year [6] - even intellectually diasabled persons susceptible to placebo effect [5]

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placebo sham procedure

References

  1. Hall KT et al. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS ONE 2012 Oct 23; 7:e48135. PMID: 23110189
  2. Howick J et al Placebo Use in the United Kingdom: Results from a National Survey of Primary Care Practitioners. PMID: 23526969 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0058247
  3. Kaptchuk TJ, Miller FG Placebo Effects in Medicine. N Engl J Med 2015; 373:8-9. July 2, 2015 PMID: 26132938 http://www.nejm.org/doi/full/10.1056/NEJMp1504023
  4. Bannuru RR et al. Effectiveness and implications of alternative placebo treatments: A systematic review and network meta-analysis of osteoarthritis trials. Ann Intern Med 2015 Jul 28 PMID: 26215539 http://annals.org/article.aspx?articleid=2398908
  5. Jensen KB et al. Certainty of genuine treatment increases drug responses among intellectually disabled patients. Neurology 2017 May 16; 88:1912. PMID: 28424273
  6. Gever J Respect the Needle in OA. Patients may be experiencing placebo effect, but it's still an effect, rheumatologist says. MedPage Today. April 19, 2018 https://www.medpagetoday.com/meetingcoverage/acrsota/72444