cytosolic phospholipase A2 delta (cPLA2-delta, phospholipase A2 group IVD, PLA2G4D)

Function: - Ca⁺²-dependent phospholipase A2 - selectively hydrolyzes glycerophospholipids in the sn-2 position - not arachidonic acid-specific but has linoleic acid-specific activity - stimulated by cytosolic Ca⁺² phosphatidylcholine + H₂O 1-acylglycerophosphocholine + a carboxylate Structure: - contains 1 N-terminal C2 domain a) associates with lipid membranes b) mediates its regulation by presenting active site to its substrate in response to elevations of cytosolic Ca⁺² - contains 1 PLA2c domain Compartment: - cytoplasm - translocates to membrane vesicles (Ca+- dependent) - translocates to perinuclear regions upon ionomycin stimulation Alternative splicing: named isoforms=2 Expression: - expressed in stratified squamous epithelia,including: skin & cervix, but not in other tissues - not detected in epidermis of normal skin Pathology: - may play a role in inflammation in psoriatic lesions - strongly expressed in the upper spinous layer of psoriatic epidermis - weakly & discontinuously in atopic dermatitis & mycosis fungoides

Properties

SIZE: MW = 92 kD entity length = 818 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: C2 domain {9-120} MOTIF: binding site FOR-BINDING-OF: phospholipid Ca+2-binding site PLA2c {273-818}

Database Correlations

UniProt Q86XP0 PFAM correlations ENZYME 3.1.1.4

References

UniProt :accession Q86XP0