plakophilin-4; p0071 (PKP4)

Function: - may play a role in junctional plaques - phosphorylated upon DNA damage, probably by ATM or ATR - interacts with PDZD2 (putative) - interacts (via the C-terminus) with FRMPD2 (via the 2nd PDZ domain) Structure: - belongs to the beta-catenin family - contains 9 ARM repeats Compartment: - cell junction, desmosome - colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells Alternative splicing: named isoforms=2; long, short

General

phosphoprotein plakophilin

Properties

SIZE: entity length = 1211 aa MW = 134 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {36-70} Ser phosphorylation site {S75} Ser phosphorylation site {S132} Ser phosphorylation site {S221} Ser phosphorylation site {S231} Ser phosphorylation site {S233} Ser phosphorylation site {S273} Tyr phosphorylation site {Y275} Ser phosphorylation site {S281} Ser phosphorylation site {S290} Ser phosphorylation site {S314} Ser phosphorylation site {S327} Ser phosphorylation site {S336} Ser phosphorylation site {S337} Tyr phosphorylation site {Y372} Tyr phosphorylation site {Y390} Ser phosphorylation site {S392} Ser phosphorylation site {S403} Ser phosphorylation site {S406} ARM repeat {415-455} MOTIF: Tyr phosphorylation site {Y415} Tyr phosphorylation site {Y420} Ser phosphorylation site {S422} Ser phosphorylation site {S438} Tyr phosphorylation site {Y470} Tyr phosphorylation site {Y478} Tyr phosphorylation site {Y482} Ser phosphorylation site {S510} Ser phosphorylation site {S512} Ser phosphorylation site {S515} ARM repeat {518-557} ARM repeat {560-599} ARM repeat {604-644} ARM repeat {660-702} ARM repeat {706-751} Ser phosphorylation site {S776} lysine-rich region {788-794} MOTIF: lysine residue (SEVERAL) ARM repeat {815-855} ARM repeat {862-901} ARM repeat {950-993} Thr phosphorylation site {T1017} Ser phosphorylation site {S1048} Ser phosphorylation site {S1049} Ser phosphorylation site {S1135} Ser phosphorylation site {S1138} Tyr phosphorylation site {Y1168}

Database Correlations

OMIM 604276 UniProt Q99569 Pfam PF00514

References

UniProt :accession Q99569