protein kinase A2

Function: 1) serine/threonine protein kinase 2) inactive form of PKA2 consists of 2 PKA2 regulatory chains & 2 cAMP protein kinase (catalytic) chains 3) activation by cAMP produces two active cAMP protein kinase monomers and a PKA2 regulatory chain dimer that binds 4 cAMP Expression: - brain specific

Properties

SIZE: gel filtration = 190 kD COMPARTMENT: intracellular membrane STATE: Inactive SUBUNITS: protein kinase A2 regulatory (2) MOTIF: PEST region cAMP-binding site (2) EFFECTOR-BOUND: cyclic AMP calmodulin binding site FOR-BINDING-OF: calmodulin cAMP-binding site (2) cAMP kinase (2) MOTIF: S/T phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site STATE: Inactive

References

Nestler & Greengard Basic Neurochemistry ch 19 1989

Components

cAMP-dependent protein kinase catalytic subunit or protein kinase A [PKA] catalytic subunit protein kinase A2 [PKA2] regulatory subunit; AKAP5; A-kinase anchor protein 79; AKAP-79 (PKA2R)