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protein kinase A1 [PKA1] regulatory subunit-alpha (tissue-specific extinguisher-1, TSE-1, PRKAR1A, PKR1, PRKAR1)
Function:
1) most abundant & widely expressed PKA regulatory subunit
2) pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, thus inhibiting activity
3) activation by cAMP produces two active cAMP protein kinase monomers & a PKA1 regulatory chain dimer that binds 4 cAMP
4) interacts with RFC2, AKAP4
5) may be involved in cell survival
6) may act as a tumor-suppressor gene in Carney complex 1 sporadic adrenal & thyroid tumors
Pathology:
1) defects in PRKAR1A associated with Carney complex 1
2) defects in PRKAR1A associated with cardiac myxoma
Related
cAMP-dependent protein kinase regulatory-alpha gene type 1 (PKA1, PRKAR1A)
protein kinase A1
General
protein kinase A1 [PKA1] regulatory subunit
Properties
SIZE: MW = 47 kD
COMPARTMENT: cytoplasm
MOTIF: myristoylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: myristate
PEST region
cAMP-binding site (2)
EFFECTOR-BOUND: cyclic AMP
Database Correlations
OMIM 188830
UniProt P10644
Kegg hsa/hsa04210
References
- Cadd et al J Biol Chem 265:19502 1990
- UniProt :accession P10644
- Atlas of Genetics and Cytogenetics in Oncology and Haematology
http://atlasgeneticsoncology.org/Genes/PRKAR1AID387.html