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pituitary adenoma/non-secreting
Most non-secreting pituitary adenomas actually secrete gonadotropins, their subunits or both.
Genetics:
Microarray analysis [2]
1) comparing different pituitary adenoma types & normal pituitary:
a) genes uniquely overexpressed 2x or >:
- guanine nucleotide binding protein, beta polypeptide
- ATPase, Ca+2 transporting, plasma membrane 1
- glutamate cysteine ligase
- ubiquitin specific protease 9, Y chromosome
- KIAA0591 protein
- KIAA0911 protein
- CBP/p300-interacting transactivator
- histone deacetylase 1
- cellular retinoic acid binding protein 2
b) genes uniquely underexpressed 2x or >:
- keratin 18
2) comparing with normal pituitary:
a) genes overexpressed 2x or >: ?
b) genes underexpressed 2x or >:
- protease inhibitor 12
- prolactin
Radiology:
- CT or MRI of sella turcica (preferably MRI); repeat in 6 months if no surgery [1]
Management:
- - asymptomatic pituitary microadenomas do not require treatment [1]
- surgery is the only effective treatment
Related
pituitary adenoma/FSH secreting
pituitary adenoma/LH secreting
General
pituitary adenoma
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 18, 19.
American College of Physicians, Philadelphia 1998, 2006, 2018, 2022.
- Evans CO et al
Novel patterns of gene expression in pituitary adenomas
identified by complementary deoxyribonucleic acid microarrays
and quantitative reverse transcription-polymerase chain
reaction.
Journal Clinical Endocrinology & Metabolism
86:3097-3107, 2001
PMID: 11443173