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pitolisant (Wakix)

Indications: - treatment of narcolepsy* * only nonscheduled treatment option FDA-approved for adult patients with narcolepsy Contraindications: - severe liver disease or ESRD - risk of QT prolongation Dosage: - QAM upon awakening Adverse effects: - insomnia (6%) - nausea (6%) - anxiety (5%). Mechanism of action: - increases synthesis & release of histamine, a wake-promoting neurotransmitter in the brain

General

H3 receptor antagonist

References

  1. Brooks M. FDA Okays Pitolisant (Wakix) for Narcolepsy. Medscape - Aug 15, 2019. https://www.medscape.com/viewarticle/916895
  2. HIGHLIGHTS OF PRESCRIBING INFORMATION WAKIX (pitolisant) tablets, for oral use https://www.wakix.com/assets/pdf/wakix_prescribinginformation_us.pdf