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piperaquine
Indications:
- treatment of Plasmodium falciparum
* used in combination with dihydroartemisinin (had been 1st line southeast Asia)
* resistance to combination first observed in Cambodia in 2008 [1]
* in 2018, > 80% of Plasmodium falciparum in some regions in Southeast Asia resistant
Interactions
drug adverse effects of antimalarials
General
antimalarial
Database Correlations
PUBCHEM cid=122262
References
- Hamilton WL, Amato R, van der Pluijm RW et al
Evolution and expansion of multidrug-resistant malaria in
southeast Asia: a genomic epidemiology study.
Lancet Infectious Diseases. July 22, 2019
PMID: 31345709 Free Article
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30392-5/fulltext
- van der Pluijm RW, Imwong M, Chau NH et al
Determinants of dihydroartemisinin-piperaquine treatment failure
in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam:
a prospective clinical, pharmacological, and genetic study.
Lancet Infectious Diseases. July 22, 2019
PMID: 31345710 Free Article
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30391-3/fulltext
- Menard D, Fidock DA
Accelerated evolution and spread of multidrug-resistant Plasmodium
falciparum takes down the latest first-line antimalarial drug
in southeast Asia.
Lancet Infectious Diseases. July 22, 2019
PMID: 31345711 Free Article
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30394-9/fulltext