pipecuronium (Arduan)

Tradename: Arduan. Indications: 1) skeletal muscle relaxation during surgery 2) skeletal muscle relaxation during endotracheal intubation 3) recommended only for procedures anticipated to last at least 90 minutes Contraindications: Caution: - for only with assisted ventilation Dosage: 1) adults: a) initial: 85-100 ug/kg IV b) maintenance: 5-25 ug/kg 2) children 1-14 years of age may be less sensitive to effects 3) infants 3 months to 1 year: adult schedule Powder for injection: 10 mg vial. Pharmacokinetics: 1) onset of action: within 2-3 minutes 2) metabolized in the liver primarily to 3 desacetyl- pipecuronium 3) elimination: 40% excreted unchanged in the urine Adverse effects: 1) common (> 10%) - hypotension, bradycardia 2) less common (> 5%) - atrial fibrillation, myocardial ischemia, thrombosis, hypertension, ventricular extrasystole, CNS depression, urticaria, hypoglycemia, hyperkalemia, muscle atrophy, anuria, respiratory depression, dyspnea

Properties

MISC-INFO: elimination route LIVER KIDNEY

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998