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phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; PIP5K1-gamma; Ptdins(4)P-5-kinase 1 gamma; phosphatidylinositol-4-phosphate 5-kinase type I gamma; PIP5KIgamma (PIP5K1C, KIAA0589)
Function:
- synpatic membrane ruffling & assembly of clathrin-coated pits at the synapse
- RAC1-dependent reorganization of actin filaments
- biosynthesis of phosphatidylinositol-4,5-bisphosphate.
- interacts with TLN1, TLN2, CSK, ARF6, AP2B1
- activated by interaction with TLN2
- interacts with AP2M1
- phosphorylation of PIP5K1C by CSK disrupts the interaction
- clathrin competes with PIP5K1C (putative)
ATP + phosphatidyl-inositol-4-phosphate = ADP + phosphatidyl-inositol-4,5-bisphosphate
Structure: contains 1 PIPK domain
Compartment:
- plasma membrane, cytoplasmic side
- detected in focal adhesion plaques, membrane ruffles & plasma membrane invaginations
Pathology:
- defects in PIP5K1C are the cause of lethal congenital contracture syndrome type 3
General
phosphoinositide-5-kinase
Properties
SIZE: entity length = 668 aa
MW = 73 kD
COMPARTMENT: cytoplasm
MOTIF: PIPK {75-443}
Mediates interaction with TLN2 {641-668}
MOTIF: Tyr phosphorylation site {Y649}
Database Correlations
OMIM correlations
MORBIDMAP 606102
UniProt O60331
Pfam PF01504
Entrez Gene 23396
Kegg hsa:23396
ENZYME 2.7.1.68
References
UniProt :accession O60331