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FYVE finger-containing phosphoinositide kinase; 1-phosphatidylinositol-4-phosphate 5-kinase; PtdIns(4)P-5-kinase p235 (PIP5K, PIKFYVE)
Function:
- supports the intracellular PIP pool & to a lesser extent, the PtdIns(4,5)P2 pool
- generates PIP from PI &, to a lesser extent, PtdIns(4,5)P2 pool from PtdIns4P
- indications that it phosphorylates the D-5 rather than the D-4 position
- role in endosome-related membrane trafficking (putative)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Structure:
- contains 1 DEP domain
- contains 1 FYVE-type Zn+2 finger
- contains 1 PI5K domain
Compartment:
- endosome membrane
- mainly associated with membranes of the late endocytic pathway
Pathology:
- defects in PIP5K3 are the cause of corneal fleck dystrophy
General
phosphoinositide-5-kinase
Properties
SIZE: entity length = 2098 aa
MW = 237 kD
MOTIF: Tyr phosphorylation site {Y46}
Zn finger Fyve-type
SITE: 158-218
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S307}
DEP domain {365-440}
Tyr phosphorylation site {Y1155}
Tyr phosphorylation site {Y1772}
active site
SITE: 1842-2098
Database Correlations
OMIM 121850
UniProt Q9Y2I7
PFAM correlations
Kegg hsa:2005
ENZYME 2.7.1.68
References
UniProt :accession Q9Y2I7