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pindolol (Visken)

Tradename: Visken. Dosage: Start 5 mg PO BID, max 60 mg/day. Tabs: 5 & 10 mg. Pharmacokinetics: -> crosses blood-brain barrier [3] Adverse effects: 1) increased serum transaminases (not hepatotoxic) 2) insomnia [3] Drug interactions: -> phenothiazines & cimetidine may increase plasma levels of pindolol Laboratory: 1) specimen: serum, plasma (EDTA, heparin) 2) methods: fluorometry, GLC, HPLC Mechanism of action: 1) beta-1, beta-2 adrenergic receptor antagonist 2) intrinsic sympathomimetic activity

Interactions

drug interactions drug adverse effects (more general classes)

General

non-specific beta-adrenergic receptor antagonist (non-specific beta-blocker)

Properties

MISC-INFO: elimination route KIDNEY LIVER 1/2life 3.6 +/- 0.6 HOURS therapeutic-range 0.5-6.2 NG/ML protein-binding 51 +/- 3% pregnancy-category B safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995
  3. Alessi C In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004