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pimecrolimus (Elidel)

Tradename: Elidel. Indications: - topical agent for treatment of mild to moderate eczema - atopic dermatitis [3,5] - severe cases of lichen planus Dosage: apply BID Elidel: 1% pimecrolimus Adverse effects: 1) may cause feeling of skin warmth or burning, esp in 1st few days 2) photosensitivity (use sunscreen) 3) increased risk of skin cancer [4,6] Mechanism of action: 1) non-steroid topical immunosuppressive agent 2) suppresses release of cytokines from T-cells & mast cells 3) IL-2 inhibitor ? 4) inhibits calcineurin (calcineurin inhibitor) Notes: Manufacturer: Novaritis

Interactions

drug interactions drug adverse effects of calcineurin inhibitors

Related

eczematous dermatitis (eczema)

General

calcineurin inhibitor topical immunomodulator (TIM)

Database Correlations

PUBCHEM correlations

References

  1. Prescriber's Letter 9(2):S1 2002
  2. Prescriber's Letter 9(3):13 2002
  3. Journal Watch 22(16):128, 2002 Wahn U et al Pediatrics 110:e2, 2002
  4. Prescriber's Letter 12(4): 2005 FDA Public Health Advisory Elidel (pimecrolimus) Cream and Protopic (tacrolimus) Ointment Detail-Document#: 210407 (subscription needed) http://www.prescribersletter.com http://www.fda.gov/bbs/topics/ANSWERS/2005/ANS01343/htm
  5. Journal Watch 25(9):75, 2005 Ashcroft DM, Dimmock P, Garside R, Stein K, Williams HC. Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials. BMJ. 2005 Mar 5;330(7490):516. Epub 2005 Feb 24. Review. PMID: 15731121 http://bmj.bmjjournals.com/cgi/content/full/330/7490/503
  6. FDA Medwatch http://www.fda.gov/medwatch/safety/2006/safety06.htm#Elidel
  7. WebMD Topical Calcineurin Inhibitors for Atopic Dermatitis. http://www.webmd.com/skin-problems-and-treatments/eczema/topical-calcineurin-inhibitors-for-atopic-dermatitis