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zinc finger protein PILOT; early growth response protein 3; EGR-3 (EGR3, PILOT)
Function:
- probable transcription factor involved in muscle spindle development
Structure:
- belongs to the EGR C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus (probable)
Expression:
- in T-cells, expressed 20 minutes following activation
General
C2H2 type zinc finger protein
early growth response protein family (EGR)
Properties
SIZE: MW = 43 kD
entity length = 387 aa
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 275-299
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 305-327
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 333-355
EFFECTOR-BOUND: Zn+2
Database Correlations
UniProt Q06889
Pfam PF00096
Entrez Gene 1960
Kegg hsa:1960
References
- UniProt :accession Q06889
- Gashler A and Sukhatme VP
Early growth response protein 1 (EGR-1): prototype of a zinc-
finger family of transcription factors.
Prog Nuclei Acid Res Mol Biol 1995, 50:191
PMID: 7754034
- Entrez Gene :accession 1960