phosphatidylinositol 3 kinase catalytic subunit alpha (PIK3CA)

Function: - phosphorylates Ptdins, Ptdins4P & Ptdins(4,5)P2 with a preference for Ptdins(4,5)P2 - heterodimer of a p110 (catalytic) & a p85 (regulatory) subunit - binds to IRS1 in nuclear extracts - interacts with RUFY3 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate Structure: - belongs to the PI3/PI4-kinase family - contains 1 C2 domain - contains 1 PI3K/PI4K domain Pathology: - defects in PIK3CA are associated: a) colorectal cancer b) breast cancer c) epithelial ovarian cancer - PIK3CA mutations also associated with - PIK3CA overgrowth syndrome - Klippel-Trenaunay-Weber syndrome Laboratory: - PIK3CA gene in cancer

Properties

SIZE: MW = 110 kD MOTIF: binding site SITE: N-TERMINAL BOUND-VIA: binding site Tyr phosphorylation site kinase domain SITE: C-TERMINAL MOTIF: ATP-binding site NAME: ATP-binding site

Database Correlations

OMIM correlations MORBIDMAP 171834 UniProt P42336 PFAM correlations Entrez Gene 5290 Kegg hsa:5290 ENZYME 2.7.1.153

References

UniProt :accession P42336